Opportunity Information: Apply for RFA RM 15 011
The National Institutes of Health (NIH) released this funding opportunity, titled "Molecular Transducers of Physical Activity Metabolomics and Proteomics Chemical Analysis Sites (U24)" (Funding Opportunity Number: RFA-RM-15-011), to build out specialized laboratory sites that would become part of the Molecular Transducers of Physical Activity Consortium (MoTrPAC). The basic idea behind MoTrPAC is to figure out how physical activity produces its health effects at a molecular level. To do that at scale, the consortium needs dedicated centers that can run high-quality, standardized metabolomics and proteomics measurements on biological samples collected from both human participants and animal models involved in structured physical activity interventions.
This opportunity uses a cooperative agreement mechanism (U24), which signals that awardees would not simply receive funds and operate independently. Instead, NIH expects active collaboration and coordination across the consortium, including shared goals, common standards, and regular data exchange. The funded Chemical Analysis Sites would be responsible for applying appropriate state-of-the-art technologies to analyze tissues and other specimens for metabolites and proteins. Beyond generating raw measurements, these sites would also contribute the resulting datasets to a public consortium database, supporting the broader scientific goal of making the information widely accessible and reusable by the research community. In addition to producing and depositing data, awardees would participate in early-stage statistical analyses aimed at identifying "fingerprints" or patterns that point to candidate molecular transducers, meaning specific molecules or molecular signatures that may mediate the biological effects of exercise and physical activity.
The opportunity falls under the health funding category and is associated with CFDA number 93.310. It was created on October 8, 2015, with an original application closing date of March 18, 2016. While the provided record does not list an award ceiling or the expected number of awards, the scope indicates that NIH was seeking a set of capable, consortium-ready sites rather than isolated one-off projects. The emphasis is on analytical capacity, rigor, and interoperability: producing comparable metabolomics and proteomics results across studies and samples, contributing to a unified database, and helping generate initial consortium-level insights.
Eligibility is broad within the United States and includes many types of domestic organizations: state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (as long as they are not institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; and small businesses. NIH also explicitly highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. At the same time, the FOA makes clear that non-U.S. entities (foreign institutions) cannot apply, and non-U.S. components of U.S. organizations are also not eligible to apply. However, foreign components, as NIH defines them in its Grants Policy Statement, are allowed, meaning a U.S.-based awardee could potentially include certain well-justified foreign collaborations or activities as part of the project under NIH rules.
In practical terms, NIH was looking for teams that could function as reliable, high-throughput analytical hubs for the consortium: processing complex biological samples from exercise interventions, generating metabolomics and proteomics data with consistent quality control, sharing outputs through a public data infrastructure, and working collaboratively on initial analyses that help map the molecular landscape of physical activity. The end product NIH is pushing toward is a set of robust molecular signatures that clarify how exercise affects tissues and systems, laying groundwork for future mechanistic studies and, potentially, new strategies to mimic or amplify the benefits of physical activity for health.Apply for RFA RM 15 011
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Molecular Transducers of Physical Activity Metabolomics and Proteomics Chemical Analysis Sites (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310.
- This funding opportunity was created on 2015-10-08.
- Applicants must submit their applications by 2016-03-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the title of this NIH funding opportunity?
The funding opportunity is titled "Molecular Transducers of Physical Activity Metabolomics and Proteomics Chemical Analysis Sites (U24)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-RM-15-011.
Which agency is offering this opportunity?
This opportunity was released by the National Institutes of Health (NIH).
What is the main purpose of this funding opportunity?
The purpose is to build specialized laboratory "Chemical Analysis Sites" that can produce high-quality, standardized metabolomics and proteomics measurements on biological samples collected from human participants and animal models involved in structured physical activity interventions, as part of the MoTrPAC consortium.
What larger program or consortium is this opportunity connected to?
It supports the Molecular Transducers of Physical Activity Consortium (MoTrPAC), which aims to understand how physical activity produces health effects at a molecular level.
What type of award mechanism does this opportunity use?
It uses a cooperative agreement mechanism (U24).
What does a U24 cooperative agreement imply for awardees?
A U24 indicates NIH expects active collaboration and coordination rather than independent, stand-alone operation. Awardees are expected to work toward shared consortium goals, follow common standards, coordinate with other consortium components, and participate in regular data exchange.
What are "Chemical Analysis Sites" expected to do under this FOA?
Chemical Analysis Sites are expected to apply appropriate state-of-the-art technologies to analyze tissues and other specimens for metabolites and proteins, produce standardized results with strong quality control, and operate as reliable analytical hubs that can support the consortium at scale.
What kinds of scientific measurements are emphasized?
The emphasis is on metabolomics and proteomics measurements, meaning chemical analysis of metabolites and proteins in biological samples.
What types of samples are expected to be analyzed?
The sites are expected to analyze tissues and other specimens collected from both human participants and animal models involved in structured physical activity interventions.
Is the goal limited to generating raw metabolomics/proteomics data?
No. In addition to generating measurements, the Chemical Analysis Sites are expected to contribute resulting datasets to a public consortium database and participate in early-stage statistical analyses to identify candidate molecular "fingerprints" or patterns linked to physical activity effects.
What is meant by "molecular transducers" in this context?
In this context, molecular transducers refer to specific molecules or molecular signatures that may mediate (help cause or transmit) the biological effects of exercise and physical activity.
What is the role of data sharing in this opportunity?
Data sharing is central. Awardees are expected to deposit the resulting datasets into a public consortium database so the information is widely accessible and reusable by the broader research community.
Are awardees expected to do any consortium-level analysis work?
Yes. Beyond data generation and deposition, awardees would participate in early-stage statistical analyses aimed at identifying molecular fingerprints or patterns that point to candidate molecular transducers.
What is the emphasis regarding standardization and interoperability?
The FOA emphasizes analytical rigor and interoperability: producing comparable metabolomics and proteomics results across studies and samples, using common standards, and contributing to a unified database to enable integrated consortium-wide insights.
What funding category is this opportunity associated with?
It falls under the health funding category.
What is the CFDA number associated with this opportunity?
The CFDA number is 93.310.
When was this funding opportunity created?
The opportunity record indicates it was created on October 8, 2015.
What was the original application closing date?
The original application closing date was March 18, 2016.
Does the provided record state the award ceiling?
No. The provided record does not list an award ceiling.
Does the provided record state the expected number of awards?
No. The provided record does not list the expected number of awards.
Based on the description, what kinds of applicants was NIH likely seeking?
The scope suggests NIH was seeking consortium-ready sites that can serve as capable, reliable, high-throughput analytical hubs, rather than isolated one-off projects.
Who is eligible to apply?
Eligibility is broad for domestic (U.S.) organizations and includes: state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (in the non-IHE nonprofit categories); for-profit organizations other than small businesses; and small businesses.
Are U.S. territories or possessions eligible?
Yes. The FOA explicitly highlights U.S. territories or possessions as eligible applicant types.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly highlighted among eligible applicant types.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The FOA explicitly highlights Alaska Native and Native Hawaiian Serving Institutions, AANAPISI institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs) as eligible applicant types.
Are eligible federal agencies included in the eligibility list?
Yes. Eligible federal agencies are explicitly highlighted as eligible applicant types.
Can non-U.S. (foreign) institutions apply directly?
No. The FOA states that non-U.S. entities (foreign institutions) cannot apply.
Can non-U.S. components of U.S. organizations apply?
No. The FOA states that non-U.S. components of U.S. organizations are not eligible to apply.
Are any types of foreign involvement allowed at all?
Yes. While foreign institutions cannot apply directly, foreign components (as defined by NIH in its Grants Policy Statement) are allowed. That means a U.S.-based awardee could potentially include certain well-justified foreign collaborations or activities under NIH rules.
What is the practical role these funded sites would play in MoTrPAC?
Practically, the sites would function as standardized analytical hubs: processing complex biological samples from exercise interventions, generating metabolomics and proteomics data with consistent quality control, sharing outputs through a public data infrastructure, and collaborating on initial analyses to help map the molecular landscape of physical activity.
What broader outcome is NIH pushing toward with this program?
The described end product is a set of robust molecular signatures that clarify how exercise affects tissues and systems, laying groundwork for future mechanistic studies and potentially informing strategies to mimic or amplify the benefits of physical activity for health.
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