Opportunity Information: Apply for RFA DA 20 003
This grant opportunity, RFA DA 20 003, is a limited-competition cooperative agreement (U24; clinical trial not allowed) from the National Institutes of Health under the Department of Health and Human Services. It supports the Adolescent Brain Cognitive Development (ABCD) Study by funding a single Data Analysis, Informatics, and Resource Center that will function as the coordinating backbone for a nationwide, multi-site, multi-modal, longitudinal cohort study following participants from late childhood (around ages 9 to 10) through adolescence and into early adulthood. The scientific purpose of the broader ABCD effort is to prospectively examine brain and behavioral development over time, with particular relevance to substance use and addiction-related outcomes within the Collaborative Research on Addiction at NIH (CRAN) framework.
The center funded through this announcement is expected to take primary responsibility for harmonizing and standardizing data collection procedures across participating sites, ensuring that measures, protocols, and workflows are consistently implemented so that data are comparable and integrable across the full study network. A major component of the work involves providing hands-on technical support to the research sites, including guidance on data capture systems, protocol adherence, and troubleshooting for the complex set of assessments typical of a multi-modal project (for example, neuroimaging, behavioral measures, and other developmental or health-related data streams). In addition to standardization and support, the center is tasked with rigorous quality control, meaning it must develop and operate processes to detect, document, and address data errors, missingness, protocol deviations, and other issues that can undermine the reliability of a long-term cohort dataset.
Beyond operational coordination, the opportunity emphasizes integrative data analysis. In practical terms, that means the center is not only a repository or help desk, but also an analytical hub that can combine data across modalities and timepoints, generate harmonized derived variables, support cross-site analytic comparability, and enable large-scale longitudinal analyses that capitalize on the breadth of the ABCD dataset. Closely tied to this analytic role is responsibility for data infrastructure: coordinating data storage, implementing informatics solutions that can handle large and complex datasets, and managing data sharing activities so that the broader research community can access study resources in a controlled, well-documented, and usable manner. Because ABCD is a long-running cohort study with repeated assessments, the data management approach must be durable and scalable, with strong governance, clear documentation, and processes that can evolve as the cohort ages and new waves of data are collected.
The announcement is supported by multiple NIH Institutes and Centers, led by NIDA and joined by NIAAA, NICHD, NIMH, NIMHD, NINDS, OBSSR, and NCI. This multi-institute participation signals that the center must be responsive to a broad set of scientific stakeholders and priorities spanning addiction, mental health, neurodevelopment, minority health and health disparities, neuroscience, behavioral and social science, and cancer-related concerns where relevant to developmental trajectories and risk behaviors. The funding mechanism is a cooperative agreement, which generally indicates substantial NIH program involvement in coordination, oversight, and collaboration as the project is carried out, rather than a fully investigator-directed research grant structure.
Eligibility is restricted: it is a limited competition in which current primary awardees are eligible to apply, and eligible applicant organizations are public and state-controlled institutions of higher education. The opportunity anticipated one award, underscoring that the intent is to fund a single centralized center rather than multiple competing hubs. The project period is extended to seven years, reflecting the long-term operational and scientific needs of maintaining study-wide informatics, quality control, and analytic capacity over a prolonged developmental window. Administrative details in the source listing include an original application closing date of July 24, 2019, and association with multiple CFDA numbers (93.242, 93.273, 93.279, 93.307, 93.313, 93.399, 93.853, 93.865), consistent with the multi-institute nature of the initiative.Apply for RFA DA 20 003
- The Department of Health and Human Services, National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Limited Competition for Adolescent Brain Cognitive Development (ABCD) Study - Data Analysis, Informatics and Resource Center (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.273, 93.279, 93.307, 93.313, 93.399, 93.853, 93.865.
- This funding opportunity was created on Apr 03, 2019.
- Applicants must submit their applications by Jul 24, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education.
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Frequently Asked Questions (FAQs): RFA DA 20 003 (ABCD Data Analysis, Informatics, and Resource Center)
What is this grant opportunity?
RFA DA 20 003 is a government grant opportunity from the National Institutes of Health (NIH), within the U.S. Department of Health and Human Services (HHS). It funds a cooperative agreement (U24; clinical trial not allowed) to support the Adolescent Brain Cognitive Development (ABCD) Study by establishing a single Data Analysis, Informatics, and Resource Center.
What is the funding mechanism and what does it imply?
The mechanism is a cooperative agreement (U24). This generally means NIH staff will have substantial involvement in coordination, oversight, and collaboration as the project is carried out, rather than it being fully investigator-directed like some other grant types.
Are clinical trials allowed under this opportunity?
No. The opportunity is designated as "clinical trial not allowed."
What is the ABCD Study, in the context of this opportunity?
In this context, the ABCD Study is a nationwide, multi-site, multi-modal, longitudinal cohort study that follows participants from late childhood (around ages 9 to 10) through adolescence and into early adulthood. The broader scientific purpose is to prospectively examine brain and behavioral development over time, with particular relevance to substance use and addiction-related outcomes within the Collaborative Research on Addiction at NIH (CRAN) framework.
What is being funded through this announcement?
This announcement supports one centralized Data Analysis, Informatics, and Resource Center that functions as the coordinating backbone for the ABCD Study across participating sites.
How many awards are anticipated?
One award is anticipated. The intent is to fund a single centralized center rather than multiple competing hubs.
What is the project period?
The project period is expected to be seven years, reflecting long-term needs for maintaining study-wide informatics, quality control, and analytic capacity across repeated assessments as participants develop.
Who is eligible to apply?
Eligibility is restricted. It is a limited competition in which current primary awardees are eligible to apply. Eligible applicant organizations are public and state-controlled institutions of higher education.
What does "limited competition" mean here?
It means the applicant pool is restricted rather than open broadly. For this opportunity, the listing specifies that current primary awardees are eligible to apply, and applicant organizations must be public and state-controlled institutions of higher education.
What is the main role of the Data Analysis, Informatics, and Resource Center?
The center is expected to serve as the coordinating backbone for the ABCD Study, with primary responsibility for harmonizing and standardizing data collection procedures across participating sites, supporting the sites operationally, running rigorous quality control, building and maintaining data infrastructure, enabling integrative analysis, and managing data sharing so study resources are accessible in a controlled and well-documented way.
What does "harmonizing and standardizing data collection procedures" involve?
It involves ensuring that measures, protocols, and workflows are consistently implemented across sites so data are comparable and can be integrated across the entire study network.
What kind of technical support is the center expected to provide to research sites?
The center is expected to provide hands-on technical support, including guidance on data capture systems, protocol adherence, and troubleshooting for complex multi-modal assessments (for example, neuroimaging, behavioral measures, and other developmental or health-related data streams).
What are the quality control expectations for the center?
The center must develop and operate rigorous processes to detect, document, and address data errors, missing data (missingness), protocol deviations, and other issues that could undermine the reliability of a long-term longitudinal cohort dataset.
Is the center only a data repository or coordination help desk?
No. The opportunity emphasizes integrative data analysis, meaning the center is also intended to function as an analytical hub in addition to coordination and informatics functions.
What does "integrative data analysis" mean in this announcement?
It refers to the center’s role in combining data across modalities and timepoints, generating harmonized derived variables, supporting cross-site analytic comparability, and enabling large-scale longitudinal analyses that make use of the breadth of the ABCD dataset.
What data infrastructure responsibilities are described?
The center is responsible for coordinating data storage, implementing informatics solutions capable of handling large and complex datasets, and managing data sharing activities so the broader research community can access study resources in a controlled, well-documented, and usable manner.
Why does the announcement emphasize durability and scalability in data management?
Because ABCD is a long-running cohort study with repeated assessments over many years. The data approach needs to remain durable and scalable as participants age and new waves of data are collected, with strong governance, clear documentation, and processes that can evolve over time.
Which NIH Institutes and Centers support this announcement?
The announcement is supported by multiple NIH Institutes and Centers. It is led by the National Institute on Drug Abuse (NIDA) and joined by NIAAA, NICHD, NIMH, NIMHD, NINDS, OBSSR, and NCI.
What does multi-institute participation imply for the center’s work?
It signals that the center must be responsive to a broad set of scientific stakeholders and priorities spanning areas such as addiction, mental health, neurodevelopment, minority health and health disparities, neuroscience, behavioral and social science, and cancer-related concerns where relevant to developmental trajectories and risk behaviors.
How is the ABCD Study connected to addiction research in this opportunity?
The broader ABCD effort is described as being particularly relevant to substance use and addiction-related outcomes and is situated within the Collaborative Research on Addiction at NIH (CRAN) framework.
What types of data or assessments are implied by "multi-modal"?
The description references a complex set of assessments typical of a multi-modal project, including examples such as neuroimaging, behavioral measures, and other developmental or health-related data streams.
What is the application closing date listed for this opportunity?
The source listing includes an original application closing date of July 24, 2019.
What CFDA numbers are associated with the opportunity?
The listing is associated with multiple CFDA numbers: 93.242, 93.273, 93.279, 93.307, 93.313, 93.399, 93.853, and 93.865.
What is the overarching goal of funding a single center rather than multiple hubs?
Based on the description, the goal is to provide a centralized coordinating backbone that standardizes procedures, maintains consistent quality control, supports integrative analysis, and manages infrastructure and data sharing across the entire nationwide network.
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| Funding Opportunity |
|---|
| Limited Competition for Adolescent Brain Cognitive Development (ABCD) Study - Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA DA 20 004 Funding Number: RFA DA 20 004 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Limited Competition for Adolescent Brain Cognitive Development (ABCD) Study - Linked Research Project Sites (Collaborative U01 Clinical Trial Not Allowed) Apply for RFA DA 20 002 Funding Number: RFA DA 20 002 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Data Coordinating and Operations Center for the ECHO IDeA States Pediatric Clinical Trials Network - 2 (U24 - Clinical Trial Required -Infrastructure) Apply for RFA OD 19 025 Funding Number: RFA OD 19 025 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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| Emergency Awards: Automatic Detection and Tracing of SARS-CoV-2 (U01 Clinical Trial Not Allowed) Apply for RFA OD 20 014 Funding Number: RFA OD 20 014 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
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| BRAIN Initiative: Targeted BRAIN Circuits Planning Projects TargetedBCPP (R34 Clinical Trials Not Allowed) Apply for RFA NS 21 014 Funding Number: RFA NS 21 014 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $225,000 |
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| BRAIN Initiative: New Technologies and Novel Approaches for Large-Scale Recording and Modulation in the Nervous System (U01) Apply for RFA NS 17 003 Funding Number: RFA NS 17 003 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
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