Opportunity Information: Apply for PAS 22 197
The Advancing Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) funding opportunity (PAS 22-197) is a National Institutes of Health (NIH) grant program run through the National Institute on Aging (NIA) under the Small Business Technology Transfer (STTR) mechanism, using the R41/R42 award structure. Its core purpose is to help small businesses, working in formal partnership with a research institution, move promising early-stage research toward practical, real-world products or services that could meaningfully improve how we prevent, diagnose, treat, or manage Alzheimer's disease and related dementias. The announcement is designed to support innovations that can ultimately make a difference for patients and caregivers, whether that means new therapeutic approaches, better tools for detection or monitoring, or technologies and services that improve care delivery and quality of life.
Because it is an STTR opportunity, the focus is strongly translational: the expectation is that applicants are not just doing basic science for its own sake, but are developing something with a clear pathway toward use in clinical practice or caregiving environments. Projects supported under this FOA can be "clinical trial optional," meaning applicants may propose studies that do not involve a clinical trial, but they also have the flexibility to include a clinical trial if it is appropriate to the stage of development and goals of the project. In practical terms, that allows a wide range of proposals, from prototype development and validation work through human testing, depending on readiness and the specific innovation.
Eligibility is limited to small businesses. Foreign institutions (non-U.S. entities) cannot apply, and non-U.S. components of U.S. organizations are also not eligible to apply as applicant entities. That said, the FOA notes that "foreign components," as defined under the NIH Grants Policy Statement, may be permitted in some cases, which typically means certain discrete parts of the work can be performed outside the U.S. when there is a strong justification (for example, access to a unique resource, population, or expertise not available domestically), but the applicant organization itself must still meet U.S. small business eligibility requirements.
Administratively, this is a discretionary grant program in the health category, associated with CFDA numbers 93.853 and 93.866. The opportunity was created on June 21, 2022, and lists an original closing date of September 5, 2025. The listed award ceiling is $1,838,436, indicating the upper bound of what might be awarded for a project under this announcement, though actual award amounts depend on the specific proposal, its scope, the applicable budget rules for the mechanism, and NIH/NIA funding decisions. Overall, the FOA is aimed at accelerating high-potential small business innovations that could push the field forward in AD/ADRD prevention, treatment, and patient-centered care.Apply for PAS 22 197
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Advancing Research on Alzheimer's Disease (AD) and AD-Related Dementias (ADRD) (R41/R42 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.853, 93.866.
- This funding opportunity was created on 2022-06-21.
- Applicants must submit their applications by 2025-09-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,838,436.00 in funding.
- Eligible applicants include: Small businesses.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Browse more opportunities from the same category: Health
Next opportunity: Botulinum Toxin Potency Assay using Tissue Chips (BoT PATCh) (U43/U44 - Clinical Trail Not Allowed)
Previous opportunity: Bureau of Land Management New Mexico Recreation and Visitor Services
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAS 22 197
Applicants also applied for:
Applicants who have applied for this opportunity (PAS 22 197) also looked into and applied for these:
| Funding Opportunity |
|---|
| Transformative Artificial Intelligence and Machine Learning Based Strategies to Identify Determinants of Exceptional Health and Life Span (R21/R33 Clinical Trial Not Allowed) Apply for RFA AG 23 033 Funding Number: RFA AG 23 033 Agency: National Institutes of Health Category: Health Funding Amount: $350,000 |
| Structural Biology of Alzheimer's Disease Related Dementias (ADRDs) Proteinopathies (R01 Clinical Trial Not Allowed) Apply for PAR 22 208 Funding Number: PAR 22 208 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Molecular Dynamics of HIV (R01 Clinical Trial Not Allowed) Apply for RFA AI 22 050 Funding Number: RFA AI 22 050 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed) Apply for RFA TR 22 030 Funding Number: RFA TR 22 030 Agency: National Institutes of Health Category: Health Funding Amount: $100,000 |
| Harnessing Technologies to Support Oral Health Promotion and Management Outside the Dental Setting (UG3/UH3 Clinical Trial Required) Apply for RFA DE 23 009 Funding Number: RFA DE 23 009 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Claude D. Pepper Older Americans Independence Centers (P30 Clinical Trial Optional) Apply for RFA AG 23 017 Funding Number: RFA AG 23 017 Agency: National Institutes of Health Category: Health Funding Amount: $925,000 |
| Impact of the Microbiome-Gut-Brain Axis on Alzheimer's Disease and Alzheimer's Disease-Related Dementias (R01 Clinical Trial Not Allowed) Apply for PAR 22 211 Funding Number: PAR 22 211 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| NIA Research and Entrepreneurial Development Immersion (REDI): Entrepreneurial Small Business Transition Award (R43/R44 Clinical Trial Optional) Apply for RFA AG 23 029 Funding Number: RFA AG 23 029 Agency: National Institutes of Health Category: Health Funding Amount: $1,838,436 |
| Building in vivo Preclinical Assays of Circuit Engagement for Application in Therapeutic Development (R01 Clinical Trial Not Allowed) Apply for PAR 22 170 Funding Number: PAR 22 170 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
| NIA Research and Entrepreneurial Development Immersion (REDI): Entrepreneurial Small Business Transition Award (R41/R42 Clinical Trial Optional) Apply for RFA AG 23 030 Funding Number: RFA AG 23 030 Agency: National Institutes of Health Category: Health Funding Amount: $1,838,436 |
| New Epidemiological Cohort Study among Asian Americans, Native Hawaiians, and Pacific Islanders (AsA-NHPI): Clinical/Community Field Centers (UG3/UH3 - Clinical Trial Not Allowed) Apply for RFA HL 23 015 Funding Number: RFA HL 23 015 Agency: National Institutes of Health Category: Health Funding Amount: $373,000 |
| Complex Integrated Multi-Component Projects in Aging Research (U19 Clinical Trial Optional) Apply for PAR 22 213 Funding Number: PAR 22 213 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| New Epidemiological Cohort Study among Asian Americans, Native Hawaiians, and Pacific Islanders (AsA-NHPI): Coordinating Center (U24 - Clinical Trial Not Allowed) Apply for RFA HL 23 016 Funding Number: RFA HL 23 016 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Novel Assays to Address Translational Gaps in Treatment Development (UG3/UH3 Clinical Trial Optional) Apply for PAR 22 169 Funding Number: PAR 22 169 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| More Monitoring of Cognitive Change, Continued (M3C3) (U2C Clinical Trial Optional) Apply for RFA AG 23 021 Funding Number: RFA AG 23 021 Agency: National Institutes of Health Category: Health Funding Amount: $4,800,000 |
| Epigenetic Mechanisms Regulating HIV CNS Latency and Neuropathogenesis Using Novel Single Cell Technologies (R21 Clinical Trial Not Allowed) Apply for RFA MH 22 281 Funding Number: RFA MH 22 281 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Epigenetic Mechanisms Regulating HIV CNS Latency and Neuropathogenesis Using Novel Single Cell Technologies (R01 Clinical Trial Not Allowed) Apply for RFA MH 22 280 Funding Number: RFA MH 22 280 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Data Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative U24 Clinical Trial Required) Apply for PAR 22 193 Funding Number: PAR 22 193 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required) Apply for PAR 22 192 Funding Number: PAR 22 192 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required) Apply for PAR 22 189 Funding Number: PAR 22 189 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAS 22 197", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.