Opportunity Information: Apply for CDC RFA GH22 2228
The Mubende Regional Mechanism for Reaching and Sustaining Epidemic Control in Uganda is a PEPFAR-supported funding opportunity from the U.S. Centers for Disease Control and Prevention (CDC) designed to accelerate and maintain HIV epidemic control in Uganda's Mubende Region while also strengthening the linked tuberculosis (TB) response. The award is structured as a cooperative agreement, meaning the CDC is expected to remain actively involved with the recipient in planning, monitoring, and technical direction, rather than simply issuing funds with minimal engagement. The opportunity is listed under CFDA 93.067 and falls within the health activity category.
The funding picture is notable in two ways. First, the Notice of Funding Opportunity states an award ceiling for Year 1 of "0 (none)," which typically signals that the agency is not setting an upper cap per award in the announcement, rather than implying no funding will be provided. At the same time, CDC indicates it anticipates approximately $20,000,000 in total Fiscal Year funding for Year 1, contingent on the availability of funds, and expects to make one award. In practice, that combination suggests a single, large implementing mechanism intended to cover a broad regional package of services. Eligibility is described as unrestricted, meaning applications are open to a wide range of entity types, subject to any additional clarifications in the full eligibility section of the announcement.
Programmatically, the grant is aimed at implementing comprehensive HIV and TB prevention, care, and treatment services with a strong focus on reaching populations that are often under-served or harder to reach. A central emphasis is HIV case finding, particularly among men, young people, and key populations, alongside ensuring smooth linkage to care and long-term retention on treatment. The care and treatment component includes antiretroviral therapy (ART) initiation and optimization, ongoing clinical follow-up, and intensified approaches to support viral suppression. In parallel, the mechanism supports TB prevention, diagnosis, and treatment, reflecting the high burden and close clinical relationship between HIV and TB, including the need for routine screening, prompt diagnosis, and timely treatment for TB among people living with HIV and other at-risk groups.
A major service delivery pillar is prevention of mother-to-child transmission (PMTCT), which typically requires strong antenatal and maternal health integration, early infant diagnosis, rapid treatment initiation for mothers and infants when indicated, and continuous follow-up to keep mothers virally suppressed throughout pregnancy and breastfeeding. The opportunity also highlights management of advanced HIV disease (AHD), signaling support for stronger clinical identification and treatment of severely immunocompromised patients, including the kinds of intensified diagnostic and prophylactic measures often needed to reduce early mortality after diagnosis or re-engagement in care.
Beyond the traditional HIV package, the announcement explicitly calls for integration with non-communicable disease (NCD) services to improve convenience and increase uptake of HIV services. This reflects a practical reality in many settings: as people live longer with HIV on effective ART, routine screening and management of conditions like hypertension, diabetes, and other chronic illnesses becomes increasingly important, and providing these services in a more "one-stop" model can reduce missed visits and improve patient experience.
The prevention portfolio includes voluntary medical male circumcision (VMMC) and HIV pre-exposure prophylaxis (PrEP). VMMC is commonly used as a high-impact biomedical prevention tool in generalized epidemic settings, while PrEP is prioritized for individuals with ongoing elevated risk of HIV acquisition, including key populations and others identified through risk screening and community outreach. The NOFO also underscores laboratory and strategic information (SI) services as essential enablers for performance and epidemic control. Specifically, it references viral load testing, which is the primary measure of ART effectiveness and a key indicator for program quality, as well as recency surveillance, which helps programs better understand patterns of recent infection and refine targeting and response.
Implementation is intended to be grounded in a health systems strengthening approach rather than a parallel system. The recipient is expected to work closely with Uganda's Ministry of Health to build the capacity of Regional Referral Hospitals and district structures so that the response is decentralized, effective, and sustainable. That language generally points to investments in management capacity, workforce development, mentoring and supportive supervision, supply chain and commodity management, data quality and use, and stronger referral networks across facility and community levels. The NOFO also emphasizes partnership with faith-based and community-based organizations to deliver more people-centered services, which commonly includes community testing strategies, peer navigation, adherence support, stigma reduction activities, community ART distribution models, and stronger follow-up for missed appointments.
The intended results are framed around improved access, quality, and coverage of HIV services with the explicit goal of reaching and sustaining the global 95-95-95 targets: 95 percent of people living with HIV knowing their status, 95 percent of those diagnosed receiving ART, and 95 percent of those on ART achieving viral suppression. Put plainly, the mechanism is designed not only to find undiagnosed individuals and start treatment, but also to keep people in care, ensure treatment is effective, and use high-quality data and laboratory systems to continuously monitor progress and adapt strategies in Mubende Region.
Administratively, the opportunity was published by the U.S. Department of Health and Human Services through the CDC Center for Global Health. The funding opportunity number is CDC RFA GH22 2228, it was created on December 30, 2021, and the original closing date was February 28, 2022, with electronic submissions due by 11:59 p.m. Eastern Time on the due date.Apply for CDC RFA GH22 2228
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Mubende Regional Mechanism for Reaching and Sustaining Epidemic Control in the Republic of Uganda under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
- This funding opportunity was created on Dec 30, 2021.
- Applicants must submit their applications by Feb 28, 2022 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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